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Mounjaro is not contraindicated for bipolar disorder, but requires careful individual assessment and close supervision by your GP and mental health team

This was highlighted in an experimental study performed on GLP-1-treated HL-1 cardiomyocytes, in which GLP1 increased calcium transients and sarcoplasmic reticular calcium contents by regulating the expression of calcium handling proteins, leading to a reduced calcium leak and thus preventing AF development [34]

Patients should be educated about the importance of maintaining adequate hydration , especially during intercurrent illness or when experiencing gastrointestinal side effects

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